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Antimicrobial

LL-37

LL-37 is the sole human cathelicidin-derived antimicrobial peptide, produced by cleavage of the hCAP18 precursor protein. It exhibits broad-spectrum activity against gram-positive and gram-negative bacteria, fungi, and enveloped viruses through membrane disruption and immunomodulatory mechanisms. Beyond direct antimicrobial action, LL-37 modulates inflammation, promotes wound healing, and bridges innate and adaptive immune responses.

Quick Facts

Also known asHuman Cathelicidin, hCAP18-derived peptide
CategoryAntimicrobial
Half-life30 minutes
Routestopical, subcutaneous
Molecular weight4493.33 Da
Chain length37 amino acids
SequenceLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
FDA statusNot approved
Storage-20°C (frozen). Reconstituted: 7 days.

Dosing Protocols

Goal Dose Frequency Route Cycle Notes
Chronic Venous Ulcers 2x/week topical 8 weeks 0.5 mg/mL topical gel, twice weekly, 2-8 weeks. Dose is concentration-based.
Diabetic Foot Ulcers 1x/day topical 8 weeks 0.5-1.6 mg/mL topical cream, daily, 2-8 weeks.
Acute Wound Healing 1x/day topical 8 weeks 1.6 mg/mL topical gel/cream, once daily.
Burn Wounds 1-2x/day topical 8 weeks 1.0 mg/mL topical gel, once-twice daily.
Immune Support (Injectable) 100 mcg 1x/day subcutaneous 12 weeks 100 mcg once daily SubQ, 4-12 weeks.

Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.

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Common Questions

What is the typical dose of LL-37?
A common dose for LL-37 is 2x/week via topical. 0.5 mg/mL topical gel, twice weekly, 2-8 weeks. Dose is concentration-based.
What is the half-life of LL-37?
The half-life of LL-37 is approximately 30 minutes. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store LL-37?
Store LL-37 at -20°C (frozen). Antimicrobial peptide that can adsorb to plastic and glass surfaces, reducing effective concentration. Use low-binding tubes. Aliquot reconstituted solution to avoid freeze-thaw cycles. Once reconstituted, use within 7 days.
Is LL-37 FDA approved?
LL-37 is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.

References