Melanocortin
PT-141
PT-141 (bremelanotide) is an FDA-approved synthetic melanocortin peptide that activates MC3 and MC4 receptors in the central nervous system. Unlike phosphodiesterase inhibitors, it acts through the hypothalamic melanocortin pathway to modulate sexual arousal. It is approved under the brand name Vyleesi for the treatment of hypoactive sexual desire disorder in premenopausal women.
Quick Facts
Also known asBremelanotide, Vyleesi
CategoryMelanocortin
Half-life2.7 hours
Routessubcutaneous, intranasal
Common vial sizes10mg
Molecular weight1025.2 Da
Chain length7 amino acids
SequenceAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
FDA statusApproved
Storage2-8°C (refrigerated). Reconstituted: 30 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Female HSDD (FDA-approved) | 1.8 mg | as-needed | subcutaneous | Continuous | FDA approved (Vyleesi). MC4R agonist. |
| Male ED | 1.5 mg | as-needed | subcutaneous | Continuous | 1-2 mg 45-60 min before activity. |
| Low Starting Dose | 500 mcg | test dose | subcutaneous | Continuous | 0.5 mg test dose. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your PT-141 Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute PT-141?
Add bacteriostatic water to your PT-141 vial (common sizes: 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of PT-141?
A common dose for PT-141 is 1.8 mg as-needed via subcutaneous. FDA approved (Vyleesi). MC4R agonist.
What is the half-life of PT-141?
The half-life of PT-141 is approximately 2.7 hours. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store PT-141?
Store PT-141 at 2-8°C (refrigerated). FDA-approved product (Vyleesi). Autoinjector form can be stored at room temperature. Reconstituted research vials should be refrigerated. Once reconstituted, use within 30 days.
Is PT-141 FDA approved?
Yes, PT-141 has FDA approval for specific medical indications.
References
- PT-141 Overview (peppedia)
- Bremelanotide (PT-141) FDA approval (pubmed)