Healing & Recovery
ARA-290
ARA-290 (cibinetide) is an 11-amino-acid peptide derived from the helix B surface of erythropoietin. It activates the innate repair receptor (a heteromer of EPO receptor and beta common receptor) to promote tissue protection and repair without stimulating erythropoiesis. Clinical studies have investigated its efficacy in diabetic neuropathy, sarcoidosis, and chronic inflammatory conditions.
Quick Facts
Also known asCibinetide
CategoryHealing & Recovery
Half-life20 minutes
Routessubcutaneous, intravenous
Common vial sizes2mg, 3mg, 5mg, 10mg
Molecular weight1257 Da
Chain length11 amino acids
SequencepGlu-Glu-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Neuropathy Treatment | 4 mg | 1x/day | subcutaneous | 4 weeks | 4mg daily subcutaneous injection. 28-day cycle. |
| Tissue Protection | 4.5 mg | 1x/day | subcutaneous | 4 weeks | 1-8mg daily. 28-day cycle. Dose varies by indication. |
| Acute Intervention | 2 mg | 3x/week | intravenous | Continuous | 2mg IV three times weekly. Variable duration. Clinical setting only. |
| Research Protocol | 4 mg | 1x/day | subcutaneous | 4 weeks | 4mg daily for 28 days. Standard research protocol. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your ARA-290 Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute ARA-290?
Add bacteriostatic water to your ARA-290 vial (common sizes: 2mg, 3mg, 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of ARA-290?
A common dose for ARA-290 is 4 mg 1x/day via subcutaneous. 4mg daily subcutaneous injection. 28-day cycle.
What is the half-life of ARA-290?
The half-life of ARA-290 is approximately 20 minutes. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store ARA-290?
Store ARA-290 at 2-8°C (refrigerated). Has been evaluated in multiple clinical trials. Lyophilized form recommended for long-term storage. Once reconstituted, use within 14 days.
Is ARA-290 FDA approved?
ARA-290 is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
Related Calculators
References
- Nonerythropoietic, tissue-protective peptides derived from tertiary structure of erythropoietin - Brines et al. (2008) (article)
- ARA 290 for treatment of sarcoidosis and chronic neuropathic pain - Dahan et al. (2013) (pubmed)
- ARA 290 improves metabolic control and neuropathic symptoms in type 2 diabetes - Brines et al. (2015) (pubmed)
- Clinical efficacy of ARA 290 (cibinetide) in sarcoidosis-associated neuropathy - Culver et al. (2017) (article)
- Cibinetide for treatment of diabetic macular edema - Lois et al. (2020) (article)
- ARA 290 reverses effects of chronic stress on depressive-like behavior and neuroplasticity - Al-Onaizi et al. (2022) (article)
- ARA 290 protects human isolated pancreatic islets against lipotoxicity - Yao et al. (2021) (article)
- Flipping the molecular switch for innate protection and repair of tissues - Collino et al. (2015) (article)
- ARA 290 in treatment of pain and inflammation in rheumatoid arthritis - Brines et al. (2013) (article)