Hormonal
Kisspeptin
Kisspeptin is a neuropeptide encoded by the KISS1 gene that acts on the GPR54 (KISS1R) receptor in hypothalamic GnRH neurons to stimulate gonadotropin-releasing hormone secretion. It plays a pivotal role in the initiation of puberty and the regulation of the hypothalamic-pituitary-gonadal axis. Clinical research has explored its diagnostic and therapeutic potential in reproductive endocrinology and fertility treatment.
Quick Facts
Also known asKISS1 Gene Product, KP-10, KP-54
CategoryHormonal
Half-life28 minutes
Routessubcutaneous, intravenous, intranasal
Molecular weight1213.42 Da
Chain length10 amino acids
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Gonadotropin Stimulation | 150 mcg | 2-3x/week | subcutaneous | 4 weeks | 100-200 mcg single or 2-3x/week SubQ, 2-4 weeks. |
| Fertility Support (KP-54) | 100 mcg | as directed | subcutaneous | 4 weeks | 0.4-1.0 nmol/kg (approx 50-150 mcg) as directed by physician, 2-4 weeks. |
| Sexual Function Research | single session | intravenous | Continuous | 1 nmol/kg/h IV infusion for 75 minutes. Clinical research setting only. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Kisspeptin Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
What is the typical dose of Kisspeptin?
A common dose for Kisspeptin is 150 mcg 2-3x/week via subcutaneous. 100-200 mcg single or 2-3x/week SubQ, 2-4 weeks.
What is the half-life of Kisspeptin?
The half-life of Kisspeptin is approximately 28 minutes. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Kisspeptin?
Store Kisspeptin at 2-8°C (refrigerated). Multiple active isoforms exist (kisspeptin-54, -14, -13, -10). Store lyophilized powder refrigerated. Reconstituted solution is relatively unstable. Once reconstituted, use within 14 days.
Is Kisspeptin FDA approved?
Kisspeptin is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- Effects of Kisspeptin on Sexual Brain Processing in Men With HSDD (2023) (pubmed)
- Effects of Kisspeptin in Women With HSDD (2022) (pubmed)
- Kisspeptin-54 triggers egg maturation in women undergoing IVF (2014) (pubmed)
- Use of kisspeptin to trigger oocyte maturation during IVF treatment (2022) (pubmed)
- Hypogonadotropic hypogonadism due to loss of function of GPR54 (2003) (pubmed)
- The GPR54 gene as a regulator of puberty (2003) (pubmed)
- Impaired kisspeptin signaling decreases metabolism and promotes obesity (2014) (pubmed)
- Kisspeptins: a multifunctional peptide system (2007) (pubmed)
- Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression (2017) (pubmed)
- Emerging Therapeutic Potential of Kisspeptin and Neurokinin B (2024) (pubmed)
- Intranasal kisspeptin administration rapidly stimulates gonadotropin release (2025) (pubmed)