Growth Hormone
MK-677
MK-677 (ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics the action of ghrelin at the GHS-R1a receptor. It produces sustained increases in growth hormone and IGF-1 levels without affecting cortisol concentrations. Unlike injectable GH secretagogues, its oral bioavailability and long duration of action allow once-daily dosing.
Quick Facts
Also known asIbutamoren, MK-0677, L-163,191
CategoryGrowth Hormone
Half-life~1 day
Routesoral
Molecular weight528.66 Da
FDA statusNot approved
StorageRoom temperature (15-25°C). Reconstituted: 90 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Body Composition / Anti-Aging | 25 mg | daily | oral | 12 weeks on / 8 weeks off | 25 mg at bedtime on empty stomach. |
| Sleep Quality | 25 mg | daily | oral | 12 weeks on / 8 weeks off | 25 mg 30 min before bed. |
| Conservative Start | 12.5 mg | daily | oral | 12 weeks on / 8 weeks off | 12.5 mg daily for tolerance assessment. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your MK-677 Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
What is the typical dose of MK-677?
A common dose for MK-677 is 25 mg daily via oral. 25 mg at bedtime on empty stomach.
What is the half-life of MK-677?
The half-life of MK-677 is approximately ~1 day. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store MK-677?
Store MK-677 at Room temperature (15-25°C). Oral compound available as capsules or liquid. Store in a cool, dry place away from excessive heat. No reconstitution required. Once reconstituted, use within 90 days.
Is MK-677 FDA approved?
MK-677 is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
Related Calculators
References
- MK-677 Overview (peppedia)
- MK-677 oral GH secretagogue (pubmed)