Healing & Recovery
PEG-MGF
PEG-MGF is a PEGylated form of mechano-growth factor, a splice variant of IGF-1 produced in response to mechanical muscle damage. The polyethylene glycol modification shields the peptide from rapid enzymatic degradation, extending its plasma half-life from minutes to hours. It promotes muscle satellite cell activation, proliferation, and fusion, supporting muscle repair and hypertrophy after injury or intense exercise.
Quick Facts
Also known asPegylated Mechano Growth Factor, IGF-1Ec splice variant, MGF-24aa E-peptide
CategoryHealing & Recovery
Routessubcutaneous, intramuscular
Common vial sizes2mg, 5mg
Molecular weight2888 Da
Chain length24 amino acids
SequenceYQPPSTNKNTKSQRRKGSTFEEHK
FDA statusNot approved
Storage-20°C (frozen). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| General Recovery | 200 mcg | 2-3x/week | subcutaneous | 8 weeks on / 8 weeks off | 200mcg per injection. 4-8 week cycles with equal off periods. |
| Targeted Muscle Recovery | 300 mcg | 2-3x/week | intramuscular | 8 weeks on / 8 weeks off | 200-400mcg range. Inject bilaterally near target muscle post-workout. Use 0.6% acetic acid for reconstitution for superior stability. |
| Injury Recovery | 300 mcg | 2-3x/week | intramuscular | 8 weeks on / 8 weeks off | 200-400mcg range. Inject near injury site. PEGylation extends half-life from minutes to hours compared to standard MGF. |
| Conservative Protocol | 150 mcg | 2x/week | subcutaneous | 6 weeks on / 6 weeks off | 100-200mcg range. Starting dose for new users. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your PEG-MGF Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute PEG-MGF?
Add bacteriostatic water to your PEG-MGF vial (common sizes: 2mg, 5mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of PEG-MGF?
A common dose for PEG-MGF is 200 mcg 2-3x/week via subcutaneous. 200mcg per injection. 4-8 week cycles with equal off periods.
How should I store PEG-MGF?
Store PEG-MGF at -20°C (frozen). PEGylation improves serum stability but the growth factor domain remains sensitive. Store lyophilized at -20°C. Administer locally near target muscle tissue for optimal effect. Once reconstituted, use within 14 days.
Is PEG-MGF FDA approved?
PEG-MGF is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.