Cognitive
Semax
Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-10), designed with enhanced proteolytic stability. It exhibits neurotrophic and neuroprotective properties through upregulation of BDNF, NGF, and modulation of dopaminergic and serotonergic systems. Approved in Russia for stroke recovery and cognitive enhancement, it is administered intranasally for optimal CNS bioavailability.
Quick Facts
Also known asACTH(4-7)-PGP
CategoryCognitive
Half-life3 minutes
Routesintranasal, subcutaneous
Common vial sizes5mg
Molecular weight813.93 Da
Chain length7 amino acids
SequenceMet-Glu-His-Phe-Pro-Gly-Pro
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 21 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Cognitive Enhancement (Nasal) | 600 mcg | 1-2x/day | intranasal | 4 weeks on / 2 weeks off | BDNF upregulation. |
| Brain Injury Recovery (Nasal) | 900 mcg | 2-3x/day | intranasal | Continuous | 900-1500 mcg 2-3x daily. |
| Cognitive Enhancement (Injectable) | 750 mcg | daily | subcutaneous | 4 weeks on / 2 weeks off | 500-750 mcg daily SubQ. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Semax Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute Semax?
Add bacteriostatic water to your Semax vial (common sizes: 5mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Semax?
A common dose for Semax is 600 mcg 1-2x/day via intranasal. BDNF upregulation.
What is the half-life of Semax?
The half-life of Semax is approximately 3 minutes. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Semax?
Store Semax at 2-8°C (refrigerated). Intranasal formulations should be stored refrigerated. Lyophilized powder is stable at room temperature for short periods during shipping. Once reconstituted, use within 21 days.
Is Semax FDA approved?
Semax is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- Semax Overview (peppedia)
- Semax neuroprotective effects (pubmed)