Anti-Aging / Longevity
SS-31
SS-31 (elamipretide, Bendavia) is a cell-permeable tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that selectively concentrates in the inner mitochondrial membrane through binding to cardiolipin. It stabilizes cristae architecture, optimizes electron transport chain efficiency, and reduces mitochondrial reactive oxygen species production. Clinical trials are evaluating its efficacy in mitochondrial myopathies, heart failure, and age-related mitochondrial dysfunction.
Quick Facts
Also known asElamipretide, Bendavia
CategoryAnti-Aging / Longevity
Half-life4 hours
Routessubcutaneous, intravenous, topical
Common vial sizes5mg, 10mg
Molecular weight639.8 Da
Chain length4 amino acids
SequenceD-Arg-Dmt-Lys-Phe-NH2
FDA statusApproved
Storage-20°C (frozen). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| General Mitochondrial Support | 7.5 mg | 1x/day | subcutaneous | 12 weeks on / 4 weeks off | 5-10mg daily subcutaneous. 4-12 week cycles. Mitochondrial-targeted tetrapeptide. FDA approved (accelerated) September 2025 for Barth syndrome. |
| Athletic Performance | 15 mg | 1x/day | subcutaneous | 12 weeks on / 4 weeks off | 10-20mg daily pre-workout. 4-12 week cycles. |
| Clinical Protocol (Barth Syndrome) | 40 mg | 1x/day | subcutaneous | 12 weeks | 40mg daily subcutaneous or IV. Phase 3 trial protocol. FDA approved dosing. |
| Acute Cardioprotection | continuous infusion | intravenous | Continuous | 0.25mg/kg/hr continuous IV infusion. Variable duration. Clinical/hospital setting only. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your SS-31 Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute SS-31?
Add bacteriostatic water to your SS-31 vial (common sizes: 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of SS-31?
A common dose for SS-31 is 7.5 mg 1x/day via subcutaneous. 5-10mg daily subcutaneous. 4-12 week cycles. Mitochondrial-targeted tetrapeptide. FDA approved (accelerated) September 2025 for Barth syndrome.
What is the half-life of SS-31?
The half-life of SS-31 is approximately 4 hours. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store SS-31?
Store SS-31 at -20°C (frozen). Contains non-standard amino acid (2,6-dimethyltyrosine). Store lyophilized powder at -20°C for long-term stability. Currently in clinical trials (elamipretide). Once reconstituted, use within 14 days.
Is SS-31 FDA approved?
Yes, SS-31 has FDA approval for specific medical indications.