Immune
Thymosin Alpha-1
Thymosin alpha-1 is a 28-amino-acid peptide originally isolated from thymic tissue (thymosin fraction 5). It enhances both innate and adaptive immunity by activating dendritic cells, promoting T-cell differentiation, and stimulating natural killer cell activity. It is approved in over 35 countries under the brand name Zadaxin for the treatment of hepatitis B and as an immune adjuvant.
Quick Facts
Also known asTa1, Zadaxin
CategoryImmune
Half-life2 hours
Routessubcutaneous, intranasal
Common vial sizes3mg, 5mg
Molecular weight3108 Da
Chain length28 amino acids
SequenceAc-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 21 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Standard Immune Support | 1.6 mg | 2x/week | subcutaneous | 26 weeks on / 4 weeks off | Approved in 35+ countries (Zadaxin). |
| Acute Conditions (Sepsis) | 1.6 mg | 2x/day | subcutaneous | 1 weeks | 1.6 mg 2x daily for 5 days. |
| Cancer / Hepatitis Support | 1.6 mg | 2x/week | subcutaneous | 26 weeks on / 4 weeks off | Enhances T-cell and NK-cell function. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Thymosin Alpha-1 Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute Thymosin Alpha-1?
Add bacteriostatic water to your Thymosin Alpha-1 vial (common sizes: 3mg, 5mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Thymosin Alpha-1?
A common dose for Thymosin Alpha-1 is 1.6 mg 2x/week via subcutaneous. Approved in 35+ countries (Zadaxin).
What is the half-life of Thymosin Alpha-1?
The half-life of Thymosin Alpha-1 is approximately 2 hours. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Thymosin Alpha-1?
Store Thymosin Alpha-1 at 2-8°C (refrigerated). Approved pharmaceutical (Zadaxin) in many countries. Lyophilized form is highly stable. Reconstitute with sterile water for injection. Once reconstituted, use within 21 days.
Is Thymosin Alpha-1 FDA approved?
Thymosin Alpha-1 is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- Thymosin Alpha-1 Overview (peppedia)
- Thymosin Alpha-1 immune modulation (pubmed)