Metabolic
Adipotide
Adipotide is a chimeric peptidomimetic that targets the prohibitin receptor complex on the vascular endothelium of white adipose tissue. By selectively disrupting blood supply to fat deposits, it induces apoptosis in adipose-associated endothelial cells, leading to fat tissue resorption. Primate studies demonstrated significant reductions in body weight and improvements in insulin resistance.
Quick Facts
Also known asProhibitin-TP01, Prohibitin-Targeting Peptidomimetic
CategoryMetabolic
Routessubcutaneous
Common vial sizes2mg, 3mg, 5mg, 10mg
SequenceCKGGRAKDC-GG-D(KLAKLAK)2
FDA statusNot approved
Storage-20°C (frozen). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Fixed-Dose Fat Loss (Primate Research) | 1x/day | subcutaneous | 4 weeks on / 4 weeks off | 0.43 mg/kg once daily. Weight-based dosing. 28-day cycle with 28-day recovery. Primate research protocol only. | |
| Dose-Finding Research Protocol | 1x/day | subcutaneous | 9 weeks | 0.10-0.75 mg/kg daily escalating dose. 63-day research protocol. Weight-based dosing. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Adipotide Protocol
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Start Tracking — FreeCommon Questions
How do I reconstitute Adipotide?
Add bacteriostatic water to your Adipotide vial (common sizes: 2mg, 3mg, 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Adipotide?
A common dose for Adipotide is 1x/day via subcutaneous. 0.43 mg/kg once daily. Weight-based dosing. 28-day cycle with 28-day recovery. Primate research protocol only.
How should I store Adipotide?
Store Adipotide at -20°C (frozen). Potent vascular-targeting agent. Store frozen for long-term stability. Research use only; significant renal side effects observed in primate studies. Once reconstituted, use within 14 days.
Is Adipotide FDA approved?
Adipotide is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys - Barnhart et al. (2011) (pubmed)
- Reversal of obesity by targeted ablation of adipose tissue - Kolonin et al. (2004) (pubmed)
- Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue - Salameh et al. (2016) (pubmed)
- Targeted Molecular MRI Detects Brown Adipose Tissue Using CKGGRAKDC Peptide Probe - Hu et al. (2018) (article)
- Comment on: A peptidomimetic targeting white fat - Criscione (2012) (article)
- Vascular-targeted nanotherapy for obesity - Hossen et al. (2012) (article)
- Prohibitin ligands in cell death and survival - Ribeiro et al. (2013) (article)
- Mixed-Chirality Prohibitin Peptide Enhances Stability and In Vivo Effects on Obesity - Chan et al. (2025) (pubmed)
- Adipose tissue-targeting nanomedicines for obesity pharmacotherapy - Wang et al. (2025) (pubmed)
- Phase 1 Evaluation of Prohibitin-TP01 in Advanced Prostate Cancer (NCT01262664) (article)