Metabolic
MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA. It activates AMPK signaling and regulates metabolic homeostasis, particularly glucose metabolism and fatty acid oxidation. Research suggests it functions as a mitochondrial retrograde signal that improves insulin sensitivity and may play a role in exercise-induced metabolic adaptations.
Quick Facts
Also known asMitochondrial ORF of the Twelve S rRNA Type-c
CategoryMetabolic
Half-life4 hours
Routessubcutaneous
Common vial sizes5mg, 10mg
Molecular weight2174.6 Da
Chain length16 amino acids
SequenceMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
FDA statusNot approved
Storage-20°C (frozen). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Metabolic Health | 10 mg | daily | subcutaneous | 12 weeks on / 4 weeks off | AMPK pathway activator. 5-10 mg daily. |
| Anti-Aging | 15 mg | 3x/week | subcutaneous | 12 weeks on / 4 weeks off | Mitochondria-derived peptide. |
| Exercise Performance | 10 mg | pre-workout | subcutaneous | 12 weeks on / 4 weeks off | 10-15 mg pre-workout. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your MOTS-c Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute MOTS-c?
Add bacteriostatic water to your MOTS-c vial (common sizes: 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of MOTS-c?
A common dose for MOTS-c is 10 mg daily via subcutaneous. AMPK pathway activator. 5-10 mg daily.
What is the half-life of MOTS-c?
The half-life of MOTS-c is approximately 4 hours. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store MOTS-c?
Store MOTS-c at -20°C (frozen). Less stable than many synthetic peptides. Store lyophilized powder at -20°C for long-term storage. Reconstituted aliquots should be used promptly. Once reconstituted, use within 14 days.
Is MOTS-c FDA approved?
MOTS-c is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- MOTS-c Overview (peppedia)
- MOTS-c regulates metabolic homeostasis (pubmed)