Metabolic
NAD+
NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme present in all living cells, serving as an electron carrier in mitochondrial oxidative phosphorylation and as a substrate for sirtuin deacetylases and PARP DNA repair enzymes. Declining NAD+ levels are associated with aging and metabolic dysfunction. Supplementation strategies aim to restore cellular NAD+ pools to support energy metabolism and genomic stability.
Quick Facts
Also known asNicotinamide Adenine Dinucleotide, NAD
CategoryMetabolic
Half-life45 minutes
Routesintravenous, subcutaneous, oral, intranasal
Common vial sizes100mg, 500mg, 1000mg
Molecular weight663.43 Da
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| General Wellness (Injectable) | 250 mg | 1-2x/week | intravenous | 12 weeks | IV infusion 100-250 mg. |
| Anti-Aging (Injectable) | 500 mg | 2-3x/week | intravenous | 12 weeks | 250-500 mg IV infusion. |
| Maintenance (SubQ) | 100 mg | weekly | subcutaneous | Continuous | 100-250 mg SubQ weekly. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your NAD+ Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute NAD+?
Add bacteriostatic water to your NAD+ vial (common sizes: 100mg, 500mg, 1000mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of NAD+?
A common dose for NAD+ is 250 mg 1-2x/week via intravenous. IV infusion 100-250 mg.
What is the half-life of NAD+?
The half-life of NAD+ is approximately 45 minutes. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store NAD+?
Store NAD+ at 2-8°C (refrigerated). NAD+ is hygroscopic and degrades rapidly in solution. Lyophilized powder should be stored desiccated. Reconstituted solutions must be used promptly. IV formulations require clinical supervision. Once reconstituted, use within 14 days.
Is NAD+ FDA approved?
NAD+ is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- NAD+ Overview (peppedia)
- NAD+ decline in aging (pubmed)