Cosmetic
AHK-Cu
AHK-Cu is a copper-binding tripeptide variant (Ala-His-Lys-Cu) related to GHK-Cu that stimulates dermal papilla cell proliferation and promotes hair follicle growth. It enhances collagen deposition and extracellular matrix remodeling in skin tissue. Cosmetic research has focused on its applications in hair loss prevention and skin repair formulations.
Quick Facts
Also known asCopper Tripeptide-3, Alanine-Histidine-Lysine copper complex
CategoryCosmetic
Routestopical, subcutaneous
Molecular weight416.9 Da
Chain length3 amino acids
SequenceAla-His-Lys
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 30 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Hair Growth - Scalp Topical | 1-2x/day | topical | 18 weeks | 0.5-1% concentration solution applied to thinning areas. 12-24 weeks minimum for results. Dose is concentration-based, not mcg. | |
| Hair Growth - Combined with Minoxidil | 1-2x/day | topical | 18 weeks | 0.3-0.5% AHK-Cu combined with minoxidil. 12-24 weeks minimum. Concentration-based dosing. | |
| Skin Regeneration | 1-2x/day | topical | 18 weeks | 0.3-1% serum or cream. 12-24 weeks minimum. Concentration-based dosing. | |
| Mesotherapy (Research) | 300 mcg | 1x/week | subcutaneous | Continuous | 0.1-0.5mg per injection site. Weekly sessions. Limited research data. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your AHK-Cu Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
What is the typical dose of AHK-Cu?
A common dose for AHK-Cu is 1-2x/day via topical. 0.5-1% concentration solution applied to thinning areas. 12-24 weeks minimum for results. Dose is concentration-based, not mcg.
How should I store AHK-Cu?
Store AHK-Cu at 2-8°C (refrigerated). Copper peptide that may oxidize with prolonged light or air exposure. Store in amber containers when possible. Commonly used in topical formulations. Once reconstituted, use within 30 days.
Is AHK-Cu FDA approved?
AHK-Cu is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- The effect of tripeptide-copper complex on human hair growth in vitro - Pyo et al. (2007) (pubmed)
- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data - Pickart & Margolina (2018) (pubmed)
- Human skin penetration of a copper tripeptide in vitro - Hostynek et al. (2011) (pubmed)
- Thermodynamically stable ionic liquid microemulsions for topical delivery and peptide application - Ahmed et al. (2023) (pubmed)
- The human tri-peptide GHK and tissue remodeling - Pickart (2008) (article)