Cognitive
DSIP
Delta sleep-inducing peptide (DSIP) is a naturally occurring nonapeptide first isolated from cerebral venous blood of rabbits during induced sleep. It modulates sleep architecture by promoting delta-wave (slow-wave) sleep and influences stress responses through neuroendocrine pathways. Research has also explored its role in opioid withdrawal, pain modulation, and normalization of disturbed circadian rhythms.
Quick Facts
Also known asDelta Sleep-Inducing Peptide
CategoryCognitive
Half-life8 minutes
Routessubcutaneous, intravenous, intranasal
Common vial sizes1mg, 2mg, 5mg
Molecular weight848.81 Da
Chain length9 amino acids
SequenceTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 14 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Sleep Enhancement | 150 mcg | 1x/day | subcutaneous | 1 weeks on / 3 weeks off | 100-200mcg once nightly. 5-10 consecutive days with 2-4 week break between cycles. |
| Chronic Pain | 275 mcg | 1x/day | subcutaneous | 1 weeks on / 3 weeks off | 250-300mcg daily. 5-10 day cycle. IV or SubQ administration. |
| Stress Management | 150 mcg | 1x/day | subcutaneous | 1 weeks on / 3 weeks off | 150mcg evening administration. 5-10 day cycle. |
| Withdrawal Support | 250 mcg | 2x/day | intravenous | 1 weeks | 200-300mcg twice daily. IV preferred. 5-10 day cycle. |
| Athletic Recovery | 125 mcg | 1x/day | subcutaneous | 1 weeks on / 3 weeks off | 100-150mcg post-training. 5-10 day cycle. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your DSIP Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute DSIP?
Add bacteriostatic water to your DSIP vial (common sizes: 1mg, 2mg, 5mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of DSIP?
A common dose for DSIP is 150 mcg 1x/day via subcutaneous. 100-200mcg once nightly. 5-10 consecutive days with 2-4 week break between cycles.
What is the half-life of DSIP?
The half-life of DSIP is approximately 8 minutes. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store DSIP?
Store DSIP at 2-8°C (refrigerated). Relatively unstable peptide in solution. Prepare fresh reconstituted solutions frequently. Administer before bedtime for sleep-related research protocols. Once reconstituted, use within 14 days.
Is DSIP FDA approved?
DSIP is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- Stroke Recovery in Rats (2021) - 120mcg/kg nasal, 7 days, enhanced motor recovery (article)
- Chronic Insomnia Double-Blind Study (1991) - Improved sleep efficiency and shorter sleep latency (article)
- Endocrine Modulation Research (1988) - DSIP modulates ACTH, cortisol, and growth hormone (article)
- Chronic Pain Pilot Study (1984) - 25 nmol IV, 10 days, 6/7 patients improved (article)
- Alcohol and Opioid Withdrawal (1984) - Symptom reduction in withdrawal patients (article)
- Sleep Pressure Induction Study (1983) - 59% increase in total sleep time within 130 minutes (article)