Hormonal
TRT (Testosterone Replacement Therapy)
Testosterone replacement therapy (TRT) involves the exogenous administration of testosterone to restore physiological hormone levels in men with clinically diagnosed hypogonadism. Available formulations include intramuscular injections (cypionate, enanthate), transdermal gels and patches, subcutaneous pellets, and oral preparations. TRT aims to alleviate symptoms of low testosterone including fatigue, decreased libido, muscle loss, and mood disturbances.
Quick Facts
Also known asTestosterone Cypionate, Testosterone Enanthate, Testosterone
CategoryHormonal
Half-life~8 days
Routesintramuscular, subcutaneous, oral, topical, intranasal
Common vial sizes5mg, 10mg
Molecular weight412.61 Da
FDA statusApproved
StorageRoom temperature (15-25°C). Reconstituted: 90 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Standard TRT (Injectable) | 150 mg | 1x/week or split 2x/week | intramuscular | Continuous | 100-200mg weekly IM or SubQ. Ongoing lifetime therapy for diagnosed hypogonadism. Testosterone Cypionate half-life ~8 days, Enanthate ~7 days. Steroid hormone, not a peptide. |
| Stable Levels (Split Dose) | 75 mg | every 3.5 days | subcutaneous | Continuous | 50-100mg every 3.5 days subcutaneous preferred for more stable levels. |
| With hCG (Fertility Preservation) | 125 mg | T weekly, hCG 2-3x/week | subcutaneous | Continuous | 100-150mg testosterone + 250-500 IU hCG. Maintains testicular function and fertility during TRT. |
| Topical TRT | 1x/day | topical | Continuous | AndroGel 1%: 50-100mg daily. AndroGel 1.62%: 40.5-81mg daily. Apply to shoulders, upper arms, abdomen. Do NOT refrigerate. | |
| Nasal TRT (Natesto) | 3x/day | intranasal | Continuous | 11mg per nostril, 3x daily (33mg total). Every 6-8 hours. FDA-approved formulation. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your TRT (Testosterone Replacement Therapy) Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute TRT (Testosterone Replacement Therapy)?
Add bacteriostatic water to your TRT (Testosterone Replacement Therapy) vial (common sizes: 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of TRT (Testosterone Replacement Therapy)?
A common dose for TRT (Testosterone Replacement Therapy) is 150 mg 1x/week or split 2x/week via intramuscular. 100-200mg weekly IM or SubQ. Ongoing lifetime therapy for diagnosed hypogonadism. Testosterone Cypionate half-life ~8 days, Enanthate ~7 days. Steroid hormone, not a peptide.
What is the half-life of TRT (Testosterone Replacement Therapy)?
The half-life of TRT (Testosterone Replacement Therapy) is approximately ~8 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store TRT (Testosterone Replacement Therapy)?
Store TRT (Testosterone Replacement Therapy) at Room temperature (15-25°C). DEA Schedule III controlled substance in the United States. Store injectable oils at room temperature; do not refrigerate as crystallization may occur. Topical formulations should be stored per manufacturer guidelines. Requires prescription and monitoring. Once reconstituted, use within 90 days.
Is TRT (Testosterone Replacement Therapy) FDA approved?
Yes, TRT (Testosterone Replacement Therapy) has FDA approval for specific medical indications.
References
- TRAVERSE Cardiovascular Safety Trial - 5,246 men, TRT noninferior to placebo for MACE (article)
- Testosterone Trials (TTrials) - 788 men, testosterone gel improved lean mass and function (article)
- Meta-Analysis: Muscular Responses to TRT - 31 RCTs, 5.7% fat-free mass increase (article)
- Long-Term Safety Registry Study - 1000+ men, up to 12 years (article)
- Testosterone Therapy in Men With Hypogonadism - Endocrine Society Guidelines (article)
- Evaluation and Management of Testosterone Deficiency - AUA Guidelines (article)