GLP-1 / Weight Management
Mazdutide
Mazdutide (LY3305677) is a dual-acting GLP-1 and glucagon receptor agonist developed for the treatment of obesity and type 2 diabetes. The glucagon receptor component enhances hepatic lipid oxidation and energy expenditure, complementing the appetite-suppressing effects mediated through GLP-1 receptor activation. Phase 3 clinical trials in China have demonstrated significant weight loss and improvements in metabolic parameters.
Quick Facts
Also known asIBI362, LY3305677, Xinermei
CategoryGLP-1 / Weight Management
Half-life~7 days
Routessubcutaneous
Common vial sizes2mg, 3mg, 5mg, 10mg
Molecular weight4563.1 Da
Chain length33 amino acids
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 42 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Weight Loss (3mg Target) | 3 mg | 1x/week | subcutaneous | 48 weeks | Start 1.5mg, escalate to 3mg after 4 weeks. Once weekly SubQ. 48-60+ weeks. |
| Weight Loss (6mg Target) | 6 mg | 1x/week | subcutaneous | 48 weeks | Escalate 2mg -> 4mg -> 6mg every 4 weeks. Once weekly SubQ. 48-60+ weeks. |
| Maximum Weight Loss (9mg Target) | 9 mg | 1x/week | subcutaneous | 60 weeks | Escalate 3mg -> 6mg -> 9mg. Once weekly SubQ. 60+ weeks. 20.1% weight loss in trials. |
| Type 2 Diabetes (Mild-Moderate) | 4.5 mg | 1x/week | subcutaneous | 48 weeks | 3-4.5mg weekly SubQ. 48-60+ weeks. HbA1c reductions 1.41-2.03%. |
| Type 2 Diabetes with Obesity (Intensive) | 7.5 mg | 1x/week | subcutaneous | 48 weeks | 6-9mg weekly SubQ. 48-60+ weeks. Superior to semaglutide in head-to-head trials. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Mazdutide Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute Mazdutide?
Add bacteriostatic water to your Mazdutide vial (common sizes: 2mg, 3mg, 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Mazdutide?
A common dose for Mazdutide is 3 mg 1x/week via subcutaneous. Start 1.5mg, escalate to 3mg after 4 weeks. Once weekly SubQ. 48-60+ weeks.
What is the half-life of Mazdutide?
The half-life of Mazdutide is approximately ~7 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Mazdutide?
Store Mazdutide at 2-8°C (refrigerated). Investigational compound in late-stage clinical trials. Store per clinical protocol guidelines. Once reconstituted, use within 42 days.
Is Mazdutide FDA approved?
Mazdutide is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- GLORY-1 Phase 3 Trial (2025) (pubmed)
- GLORY-2 Phase 3 Trial - 20.1% Weight Loss (2025) (article)
- DREAMS-3 Phase 3 - Superiority vs Semaglutide (2025) (article)
- Systematic Review & Meta-Analysis of 7 RCTs (2024) (pubmed)
- Phase 2 Type 2 Diabetes Trial (2024) (pubmed)
- Phase 1b High-Dose Safety Trial (2022) (pubmed)
- Phase 2 Overweight/Obesity Trial (2023) (article)
- Pharmacokinetic Comparison Review (2025) (article)