GLP-1 / Weight Management
Tirzepatide
Tirzepatide is an FDA-approved dual GIP and GLP-1 receptor agonist engineered for the treatment of type 2 diabetes and obesity. It combines glucose-dependent insulinotropic polypeptide activity with glucagon-like peptide-1 signaling, producing potent glycemic control and substantial weight loss. Clinical trials have shown it to be among the most effective agents for weight reduction in its class.
Quick Facts
Also known asMounjaro, Zepbound, LY3298176
CategoryGLP-1 / Weight Management
Half-life~5 days
Routessubcutaneous
Common vial sizes5mg, 10mg, 15mg, 30mg
Molecular weight4813.55 Da
Chain length39 amino acids
SequenceHis-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-Gly-Gly-Gly-Gly-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys
FDA statusApproved
Storage2-8°C (refrigerated). Reconstituted: 42 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Weight Loss | 15 mg | weekly | subcutaneous | Continuous | Dual GLP-1/GIP agonist. FDA approved (Mounjaro/Zepbound). SURMOUNT-1: 22.5% weight loss. Titration: Week 1: 2.5 mg → Week 5: 5 mg → Week 9: 7.5 mg → Week 13: 10 mg → Week 17: 12.5 mg → Week 21: 15 mg |
| Diabetes Management | 10 mg | weekly | subcutaneous | Continuous | For T2D with moderate weight loss goals. Titration: Week 1: 2.5 mg → Week 5: 5 mg → Week 9: 7.5 mg → Week 13: 10 mg |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Tirzepatide Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute Tirzepatide?
Add bacteriostatic water to your Tirzepatide vial (common sizes: 5mg, 10mg, 15mg, 30mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Tirzepatide?
A common dose for Tirzepatide is 15 mg weekly via subcutaneous. Dual GLP-1/GIP agonist. FDA approved (Mounjaro/Zepbound). SURMOUNT-1: 22.5% weight loss.
What is the half-life of Tirzepatide?
The half-life of Tirzepatide is approximately ~5 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Tirzepatide?
Store Tirzepatide at 2-8°C (refrigerated). Prefilled pens may be stored at room temperature (up to 30°C) for 21 days if needed. Do not freeze. Once reconstituted, use within 42 days.
Is Tirzepatide FDA approved?
Yes, Tirzepatide has FDA approval for specific medical indications.
References
- Tirzepatide Overview (peppedia)
- Tirzepatide SURMOUNT-1 results (pubmed)