GLP-1 / Weight Management
Retatrutide
Retatrutide is a novel triple-agonist peptide that simultaneously activates GLP-1, GIP, and glucagon receptors. This tri-receptor engagement produces synergistic effects on glucose homeostasis, appetite suppression, and energy expenditure. Phase 2 clinical trials demonstrated significant body weight reductions, making it one of the most potent investigational anti-obesity peptides.
Quick Facts
Also known asLY3437943
CategoryGLP-1 / Weight Management
Half-life~6 days
Routessubcutaneous
Common vial sizes3mg, 5mg, 10mg
Molecular weight4731.33 Da
Chain length39 amino acids
SequenceHis-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 42 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Weight Loss | 4 mg | weekly | subcutaneous | Continuous | Triple agonist (GLP-1/GIP/glucagon). Titrate slowly to manage GI side effects. Phase III showed 28.7% weight loss at 68 weeks. Titration: Week 1: 500 mcg → Week 5: 1 mg → Week 9: 2 mg → Week 13: 4 mg → Week 17: 8 mg → Week 21: 12 mg |
| T2D Management | 4 mg | weekly | subcutaneous | Continuous | Conservative titration for T2D. HbA1c reduction up to 2.16% in Phase II. Titration: Week 1: 500 mcg → Week 5: 1 mg → Week 9: 4 mg → Week 13: 8 mg |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Retatrutide Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute Retatrutide?
Add bacteriostatic water to your Retatrutide vial (common sizes: 3mg, 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Retatrutide?
A common dose for Retatrutide is 4 mg weekly via subcutaneous. Triple agonist (GLP-1/GIP/glucagon). Titrate slowly to manage GI side effects. Phase III showed 28.7% weight loss at 68 weeks.
What is the half-life of Retatrutide?
The half-life of Retatrutide is approximately ~6 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Retatrutide?
Store Retatrutide at 2-8°C (refrigerated). Investigational compound. Store in original packaging to protect from light. Once reconstituted, use within 42 days.
Is Retatrutide FDA approved?
Retatrutide is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.
References
- Retatrutide Overview (peppedia)
- Retatrutide triple agonist Phase II results (pubmed)