GLP-1 / Weight Management
Semaglutide
Semaglutide is an FDA-approved GLP-1 receptor agonist used for the treatment of type 2 diabetes and chronic weight management. It mimics the incretin hormone GLP-1, stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptying. Its acylated side chain enables albumin binding, extending its half-life to approximately one week.
Quick Facts
Also known asOzempic, Wegovy, Rybelsus
CategoryGLP-1 / Weight Management
Half-life~7 days
Routessubcutaneous, oral
Common vial sizes3mg, 5mg, 10mg
Molecular weight4113.64 Da
Chain length31 amino acids
SequenceHis-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
FDA statusApproved
Storage2-8°C (refrigerated). Reconstituted: 56 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Weight Loss (Injectable) | 2.4 mg | weekly | subcutaneous | Continuous | FDA approved (Wegovy). Titrate every 4 weeks. SELECT trial: 20% MACE reduction. Titration: Week 1: 250 mcg → Week 5: 500 mcg → Week 9: 1 mg → Week 13: 1.7 mg → Week 17: 2.4 mg |
| Diabetes Management | 1 mg | weekly | subcutaneous | Continuous | FDA approved (Ozempic). 0.5-1 mg weekly for T2D. Titration: Week 1: 250 mcg → Week 5: 500 mcg → Week 9: 1 mg |
| Oral Diabetes (Rybelsus) | 14 mg | daily | oral | Continuous | Oral formulation. Take on empty stomach with small sip of water. Titration: Week 1: 3 mg → Week 5: 7 mg → Week 9: 14 mg |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
Track Your Semaglutide Protocol
Log doses, manage vial inventory, set injection reminders, and visualize blood concentration levels.
Start Tracking — FreeCommon Questions
How do I reconstitute Semaglutide?
Add bacteriostatic water to your Semaglutide vial (common sizes: 3mg, 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Semaglutide?
A common dose for Semaglutide is 2.4 mg weekly via subcutaneous. FDA approved (Wegovy). Titrate every 4 weeks. SELECT trial: 20% MACE reduction.
What is the half-life of Semaglutide?
The half-life of Semaglutide is approximately ~7 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Semaglutide?
Store Semaglutide at 2-8°C (refrigerated). Prefilled pens may be stored at room temperature (up to 30°C) for 56 days. Protect from direct sunlight. Once reconstituted, use within 56 days.
Is Semaglutide FDA approved?
Yes, Semaglutide has FDA approval for specific medical indications.
References
- Semaglutide Overview (peppedia)
- Semaglutide cardiovascular outcomes (SELECT trial) (pubmed)
- Semaglutide weight loss mechanism (article)