GLP-1 / Weight Management
Survodutide
Survodutide is a dual-acting GLP-1 and glucagon receptor agonist developed by Boehringer Ingelheim for obesity and metabolic liver disease. The glucagon component promotes hepatic fat oxidation and thermogenesis while the GLP-1 component provides appetite suppression and glycemic regulation. Phase 3 clinical trials are investigating its efficacy in both obesity and metabolic dysfunction-associated steatohepatitis (MASH).
Quick Facts
Also known asBI 456906
CategoryGLP-1 / Weight Management
Half-life~7 days
Routessubcutaneous
Common vial sizes2mg, 3mg, 5mg, 10mg
Chain length29 amino acids
FDA statusNot approved
Storage2-8°C (refrigerated). Reconstituted: 42 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Obesity - Conservative Titration | 600 mcg | 1x/week | subcutaneous | 24 weeks | Start at 0.6mg, titrate up over 24 weeks in 4-week intervals. Dual GLP-1/Glucagon receptor agonist with C18 fatty acid acylation. |
| Obesity - Standard Protocol | 4.8 mg | 1x/week | subcutaneous | 24 weeks | 3.6-6.0mg weekly after titration. Phase 2 showed 14.9% mean weight loss at highest dose over 46 weeks. |
| MASH Treatment | 4.8 mg | 1x/week | subcutaneous | 48 weeks | 2.4-4.8mg weekly for 48 weeks. Phase 2 showed MASH improvement in 62% at 4.8mg vs 14% placebo. |
| Type 2 Diabetes | 2.7 mg | 1x/week | subcutaneous | 16 weeks | 0.3-2.7mg weekly for 16 weeks. Greater weight loss than semaglutide (-8.7% vs -5.3%). HbA1c reduction -1.6%. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
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Start Tracking — FreeCommon Questions
How do I reconstitute Survodutide?
Add bacteriostatic water to your Survodutide vial (common sizes: 2mg, 3mg, 5mg, 10mg). The amount of BAC water depends on your desired concentration. Use our reconstitution calculator for exact measurements.
What is the typical dose of Survodutide?
A common dose for Survodutide is 600 mcg 1x/week via subcutaneous. Start at 0.6mg, titrate up over 24 weeks in 4-week intervals. Dual GLP-1/Glucagon receptor agonist with C18 fatty acid acylation.
What is the half-life of Survodutide?
The half-life of Survodutide is approximately ~7 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Survodutide?
Store Survodutide at 2-8°C (refrigerated). Investigational compound in clinical development. Store per clinical protocol guidelines. Once reconstituted, use within 42 days.
Is Survodutide FDA approved?
Survodutide is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.