Metabolic
Tesofensine
Tesofensine is a novel triple monoamine reuptake inhibitor that blocks the presynaptic reuptake of serotonin, norepinephrine, and dopamine. Originally developed for Parkinson's disease and Alzheimer's, its pronounced weight-loss effect redirected its clinical development toward obesity treatment. Phase 3 trials demonstrated significant appetite reduction and weight loss exceeding that achieved with most approved anti-obesity medications.
Quick Facts
Also known asNS2330
CategoryMetabolic
Half-life~9 days
Routesoral
FDA statusNot approved
StorageRoom temperature (15-25°C). Reconstituted: 90 days.
Dosing Protocols
| Goal | Dose | Frequency | Route | Cycle | Notes |
|---|---|---|---|---|---|
| Standard Weight Loss | 500 mcg | 1x/day (morning) | oral | 24 weeks | 0.5mg oral once daily in the morning. TIPO-1 trial showed 9.2% weight reduction at this dose. Triple monoamine reuptake inhibitor (dopamine, norepinephrine, serotonin). Half-life 9.2 days. |
| Conservative/Starting Dose | 250 mcg | 1x/day (morning) | oral | 24 weeks | 0.25mg starting dose. May increase heart rate 5-8 bpm. Morning dosing only due to insomnia risk. |
| Maximum Studied Dose | 1 mg | 1x/day | oral | 24 weeks | 1.0mg daily was the maximum studied dose. Up to 10.6% weight loss. Contraindicated with MAOIs, SSRIs, SNRIs, and stimulants. |
Protocols shown are for informational purposes only. Consult a healthcare provider before starting any peptide protocol.
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Start Tracking — FreeCommon Questions
What is the typical dose of Tesofensine?
A common dose for Tesofensine is 500 mcg 1x/day (morning) via oral. 0.5mg oral once daily in the morning. TIPO-1 trial showed 9.2% weight reduction at this dose. Triple monoamine reuptake inhibitor (dopamine, norepinephrine, serotonin). Half-life 9.2 days.
What is the half-life of Tesofensine?
The half-life of Tesofensine is approximately ~9 days. This determines how long the peptide remains active in your body and influences dosing frequency.
How should I store Tesofensine?
Store Tesofensine at Room temperature (15-25°C). Oral small molecule, not a peptide. Store in a cool, dry place. Available as capsules; no reconstitution needed. Controlled substance status may vary by jurisdiction. Once reconstituted, use within 90 days.
Is Tesofensine FDA approved?
Tesofensine is not FDA approved and is available for research purposes only. It has not been evaluated by the FDA for safety or efficacy in humans.